Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid

A silica supported sulfuric acid catalyzed [3+2] cycloaddition of nitriles and sodium azide to form 5-substituted 1H-tetrazoles is described. The protocol can provide a series of 5-substituted 1H-tetrazoles using silica sulfuric acid from nitriles and sodium azide in DMF in 72%-95% yield.

متن کامل

arylaminotetrazoles : via [2+3] cycloaddition of nitriles and sodium azide via solid acid catalysis

The [3+2] cycloaddition between various nitriles and sodium azide proceeds smoothly in the presence of zeolite and sulfated Zircona as effective catalyst and in the water and DMF/MeOH, to give the corresponding arylaminotetrazoles in good to high yields. The reaction most probably precedes through the in situ formation of a catalyst azide species, followed by a successive [3+2] cycloaddition wi...

متن کامل

Efficient synthesis of arylaminotetrazoles as via [2+3] cycloaddition of nitriles and sodium azide via solid acid catalysis

The [3+2] cycloaddition between various nitriles and sodium azide proceeds smoothly in the presence of zeolite and sulfated Zircona as effective catalyst and in the water and DMF/MeOH, to give the corresponding arylaminotetrazoles in good to high yields. The reaction most probably precedes through the in situ formation of a catalyst azide species, followed by a successive [3+2] cycloaddition wi...

متن کامل

An efficient synthesis of arylaminotetrazoles as via [2+3] cycloaddition of nitriles and sodium azide via solid acid catalysis

The [3+2] cycloaddition between various nitriles and sodium azide proceeds smoothly in the presence of zeolite and sulfated Zircona as effective catalyst and in the water and DMF/MeOH, to give the corresponding arylaminotetrazoles in good to high yields. The reaction most probably precedes through the in situ formation of a catalyst azide species, followed by a successive [3+2] cycloaddition wi...

متن کامل

Mesoporous ZnS nanospheres: a high activity heterogeneous catalyst for synthesis of 5-substituted 1H-tetrazoles from nitriles and sodium azide.

Mesoporous ZnS nanospheres is a novel heterogeneous catalyst for synthesis of 5-substituted 1H-tetrazoles from various nitriles and sodium azide with excellent catalytic performance.

متن کامل

Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid

نویسندگان

چکیده

منابع مشابه